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Leibel (1) Mice plump black harboring mutations in the obese (ob) and diabetes (db) plump black genes display similar phenotypes, and it has been proposed that these genes encode the ligand and receptor, respectively, for a physiologic pathway that regulates body weight. The cloning of ob, and the demonstration that it encodes a secreted protein (leptin) that binds specifically to a receptor (OB-R) in the brain, have validated critical aspects of this hypothesis. Here it is shown by genetic mapping and genomic analysis that mouse db, rat fatty (a homolog of db), and the gene encoding the OB-R are plump black the same gene. S. C. Chua Jr., W. K. Chung, X. S. Wu-Peng, Y. Zhang, S.-M. Liu, R. L. Leibel, Laboratory of Human Behavior and Metabolism, Rockefeller University, 1230 York Avenue, Box 181, New York, NY 10021, USA. L. Tartaglia, Millennium Pharmaceuticals, 640 Memorial Drive, Cambridge, MA, 02139, USA. This article has been cited by other articles: (Search Google Scholar for Other Citing Articles) Obesity and the role of adipose tissue in inflammation and metabolism.
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