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results have general implications for nutritional approaches in biochemistry and cell biology, and ultimately on disease processes. The physiologic effect of dietary fat can be significantly modulated by the presence of carbohydrate and the associated hepaticfatty acid hormonal changes. The description "high fat diet" is thus an inadequate way to characterize a diet. One must also specify the level of carbohydrate. The principle hepaticfatty acid that dietary fat might play a relatively passive role in metabolism and that the disposition of fat is regulated by the hormonal state stimulated by carbohydrate is taught in elementary courses in biochemistry but remains an under-appreciated hepaticfatty acid factor in many studies, possibly due to the emphasis on low-fat recommendations of nutritional agencies. Because of the requirement of brain cells for glucose (or ketones) for energy metabolism and, in particular, because of the known involvement of insulin in regulating secretase (proteolytic enzyme in β-amyloid production) (e.g.
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