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| plump asian , state, immunizations, 24 7 fat girls , hours postchallenge, | Increased blood plasma concentrations of low density lipoproteins (LDL) and decreased concentrations of high density lipoproteins (HDL) both contribute to big plump plumpers galleries com increased CHD in man and monkeys. Pathways regulating plasma lipoprotein concentrations are under study. In addition, increased LDL cholesteryl oleate content has been associated with increased CAA. Isolated, big plump plumpers galleries com perfused primate livers have been used to demonstrate that big plump plumpers galleries com hepatic cholesteryl oleate secretion rate is correlated with LDL cholesteryl oleate enrichment and increased CAA. The enzyme in the liver responsible for cholesteryl oleate formation and secretion has been identified as acyl-CoA:cholesterol acyltransferase 2 (ACAT2). |
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| Interests: Teaching: Disturbances in Plasma Lipoprotein Metabolism, Cholesterol Biosynthesis and Metabolism, Atherosclerosis and plump asian Nutrition, Pathophysiology of Cholesterol and Bile Acids Research: Nutrition in Atherosclerosis, Bietary Fatty Acids in Cardiovascular Disease, Hepatic Cholesterol Metabolism and Gene Regulation, Primate Liver Perfusion, Plasma Lipoprotein Metabolism, Cholesterol Ester Formation Current Project: Cholesterol Metabolism, Lipoproteins, plump asian Primates Complications arising from coronary heart disease plump asian are the number one cause of death in our country. Atherosclerosis is the underlying disease process. We have developed nonhuman primate (monkey) models of diet-induced coronary artery atherosclerosis (CAA). We are attempting to define molecular mechanisms through which dietary fatty acids modify plasma lipoprotein distribution and composition and their respective roles in CAA. |
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