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In fact, this is true for any population-based study, and only a health care professional can ultimately determine the most appropriate (dietary) advice for any person. However, the effect of carbohydrates on total:HDL cholesterol justifies some caution in the application of high-carbohydrate plump thumbs diets to the prevention of heart disease. ACKNOWLEDGMENTS This study was planned, executed, and reported by RPM, PLZ, and MBK. ADMK assisted with the statistical analysis and data interpretation. None of the authors plump thumbs had any financial or personal conflict of interest. REFERENCES TOP ABSTRACT INTRODUCTION METHODS RESULTS DISCUSSION REFERENCES Received for publication plump thumbs August 5, 2002. Accepted for publication November 22, 2002.

However, as long as information directly linking the cherries consumption of certain fats and oils with CAD is lacking, we can never be sure what such fats and oils do to CAD risk. The situation is much clearer for replacement of SFAs with cis unsaturated fatty acids. In that case, the effects on surrogate lipid markers (Tables cherries 1 and 2), the epidemiologic findings (89), and the results of controlled clinical trials (104) all suggest that replacement of SFAs with cis unsaturated fatty acids reduces CAD risk. For trans fatty acids, the effect on lipid markers is strongly supported by prospective cherries epidemiologic findings (95, 112). Studies such as ours can predict the effects of fats on plasma lipids, but they cannot determine whether a fat will cause CAD. Finally, it should be emphasized that our results may apply only to populationwide issues of lipid management and not to individual patients, whereas total:HDL cholesterol may not be useful for subjects with specific lipid abnormalities such as greatly decreased HDL- or increased LDL-cholesterol concentrations.

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