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Lucas et al13,15 indicated that breast milk includes plump ebony biological factors that may be beneficial for mental development in preterm infants. This may be attributable to AA and DHA plump ebony in the breast milk. However, studies on the effect of adding preformed very-long-chain n-3 and n-6 PUFAs to infant formulas have been inconclusive, because some plump ebony studies of visual acuity, problem solving, and general neurologic development found enhanced performance,6,18–22 whereas others showed no effect in term infants.23–26 In 1 study, infants who received formula with DHA and without AA scored lower than infants in the breast milk or control formula groups on language assessments at 14 months of age.27 Similar studies have been performed on infants who were born prematurely. Premature infants are probably more vulnerable to DHA deficiency than are term infants, because they do not receive the third-trimester intrauterine supply of DHA. They have small tissue stores, the metabolic transformation via elongation and desaturation of fatty acids is insufficient, and the intake of DHA from infant formulas is small.4,5
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