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The cloning of ob, and the demonstration that it encodes a secreted protein (leptin) that binds specifically to a receptor (OB-R) in the brain, have girls with fat ass validated critical aspects of this hypothesis. Here it is shown by genetic mapping and genomic analysis that mouse db, girls with fat ass rat fatty (a homolog of db), and the gene encoding the OB-R are the same gene. S. C. Chua Jr., W. K. Chung, X. S. Wu-Peng, Y. Zhang, S.-M. Liu, R. L. Leibel, Laboratory of Human Behavior and Metabolism, Rockefeller University, 1230 York Avenue, Box 181, New York, NY 10021, USA. L. Tartaglia, Millennium girls with fat ass Pharmaceuticals, 640 Memorial Drive, Cambridge, MA, 02139, USA. This article has been cited by other articles: (Search Google Scholar for Other Citing Articles) Obesity and the role of adipose tissue in inflammation and metabolism. A. S Greenberg and M. S Obin (2006).Am. J. Clinical Nutrition 83: 461S-465S | Abstract » | Full Text » | PDF » Angiotensin II Type 1 Receptor Blockade Improves {beta}-Cell Function and Glucose Tolerance in a Mouse Model of Type 2 Diabetes.
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