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| fatty acid manufacturers, government, transfused, animal sciences, allergy, u.s., fat ugly girls , fatty acid companies ecplaza, national library of medicine, nutrition, | Marketers claim that chitosan-based supplements "trap" or absorb large quantities of dietary fat and inhibit intestinal fat absorption. The particular brand we studied claimed on its packaging that it could trap 10.8 times its own weight in fat and compared this to other products trapping an average of 3.87 times their own weight anti aging in fat. anti aging These results are based on an in vitro assay that has not been published (3) . The conclusion anti aging is then drawn that such fat trapping in a test tube will translate into fat trapping and subsequent weight (fat) loss in humans. Mechanistically, for this supplement to be effective as stated, the following must be true: 1) it binds in vivo some requisite amount of fat when taken as directed, and 2) the binding and excretion in that manner of that amount of fat must be clinically significant and lead to weight loss. |
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| The demand for weight loss products is a potent stimulus for the weight loss supplement industry. In 1999, fat ugly girls U.S. consumers spent over $35 billion on weight loss aids (1) . A 2002 report by the U.S. Federal Trade Commission found that, in a sample of fat ugly girls 300 weight loss–related advertisements, 55% made at least one claim that was "either very likely false or lacks sufficient evidence" (1) . Clinical research published in well-respected peer-reviewed journals is critical to supporting or challenging such claims. Until more clinical studies are done to evaluate such weight loss fat ugly girls supplements, the unsubstantiated claims are likely to continue. The Federal Trade Commission has legally challenged the efficacy of a number of dietary supplements purported to aid weight loss, including chitosan (1) (2) . |
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