Such genes are markers tocopherol concentration liverdisease
aids, diseases, eli lilly, nutritional supplement, liverdisease, renal, norwegian fish oil, racine, cod liver oil, plump up , army, hepatitis g, coconut fatty acid , statins, ob/gyn, Once identified, these compounds will be tested for insulin sensitization in other systems. Insulin sensitizing compounds can be developed tocopherol concentration into drugs for the treatment of type 2 diabetes. Similarly, this insulin responsive cell tocopherol concentration line will also be used in cDNA tocopherol concentration and siRNA screening to identify novel genes that play a role in insulin signaling.   Team Members Miah Gilmore Shih-Min (Alex) Huang Sonia Lari Sandy Lau David Lloyd Mike Richardson Richard Savary Publications Donaldson KM, Yin H, Gekakis N, Supek F, and Joazeiro CAP. Ubiquitin signals protein traffiacking via ineraction with a novel ubiquitin interaction domain in the membrane fusion regulator, Vps9p. Curr. Biol. 2003; 13; 258-262. Sangoram AM, Saez L, Antoch MP, Gekakis N, Staknis D, Whiteley A, Fruechte EM, Vitaterna MH, Shimomura K, King DP, Young MW, Weitz CJ, Takahashi JS.
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Such genes are markers of insulin resistance and candidates in the cause of type 2 diabetes. Follow-up of these genes will lead us to the mechanism of insulin resistance at the transcriptional level. We have constructed several insulin responsive cell lines in liverdisease order to take advantage of GNF's cDNA and small molecule screening capability. To alleviate the prevalent problem of insulin resistance, we have begun a screen, in conjunction with GNF's lead discovery group, liverdisease for small molecules that can sensitize cells to the actions of insulin. The insulin reporter liverdisease cell line has been screened against GNF's collection of more than a million compounds to look for molecules which can potentiate insulin's actions in this cell line.
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