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| glycerol and fatty acids , omega 3 fatty acid, plump girl , plump granny , addicts, nurse, alfalfa silage, on, healthcare, study, docosahexaenoic acid, game, investigation, antiaging, fatty acid products, parenteral vitamin e, raw milk, | Cirrhosis is described less frequently in adults, 7% to 16%2,9,10 and is absent in children. Natural History: Longitudinal studies with nonalcoholic fatty liver serial biopsies and comparable follow-up are limited. In the results of three series combined for which the follow-up histopathology nonalcoholic fatty liver of 28 patients is available, only one improved (3%), 15 of 28 (54%) were unchanged, and 12 of 28 (43%) developed progression of fibrosis during one- to seven-year periods.5,9,10 During a similar follow-up nonalcoholic fatty liver period, the progression to cirrhosis occurs in approximately 8% to 17% of patients with NASH,9,10 compared with 38% to 50% of patients with alcoholic hepatitis.15,16 The survival rates of 65 patients with alcoholic hepatitis were compared with those of 30 patients with NASH using a Kaplan-Meir curve. |
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| Histologic Features: The strict definition for the histologic diagnosis of NASH includes in addition to steatosis and inflammation, either hepatocyte ballooning or degeneration or hepatic fibrosis. The fatty liver is mainly macrovesicular and primarily in zone 3 (centrilobular), but raw milk it may be microvesicular or mixed, accompanied by fat cysts and distributed also in zone 2 and 3.2 Focal necrosis are usually centrilobular9 and the cellular response involves lymphocytes, mononuclear cells and neutrophils. raw milk Hepatocyte ballooning is present and Mallory hyaline bodies are described in 0% to raw milk 91% of cases.2,6-10 These hyaline bodies are usually sparse, small and centrilobular. The ultrastructure of Mallory bodies in patients with NASH are similar to those seen in patients with alcoholic hepatitis.14 Fibrosis associated with NASH is characterized by early zone 3 pericellular or perivenular involvement. The prevalence of mild to moderate fibrosis is recorded in 76% to 100% of cases,2,7-9 while severe fibrosis varies from 15% to 50%.2,7-10 |
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