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The initial response of scientists to the discovery of leptin was to plump woman hope that human obesity is the result of leptin plump woman deficiency, in the same way that type 1 diabetes is due to a deficiency of insulin. What plump woman scientists discovered, however, was that overweight people have high levels of leptin. Their leptin just isn’t working properly. It does not suppress appetite or increase metabolic rate the way it should. This condition has been called leptin resistance. It is sometimes measured by comparing the circulating level of leptin to the basal metabolic rate (resting energy expenditure). Leptin resistance has been compared to insulin resistance, which occurs in type 2 diabetes. In leptin resistance, as in insulin resistance, the hormone itself is fully functional and circulates at a high concentration in blood.
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