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Macrophages are scavenger cells; their job is literally to gobble up foreign organisms and cellular debris. Macrophages seem to be drawn to body fat because fat cells tend to leak and break open, especially in people with abdominal obesity. Macrophages move into the children'snutrition research center leaky fat tissue in order to clean children'snutrition research center up children'snutrition research center and then they themselves begin to release TNF-alpha and IL-6. Here is the vicious cycle of obesity and leptin resistance: Extra fat produces chronic, low-grade inflammation. The chronic inflammation produces a chronic anti-inflammatory response, led by SOCS molecules. The SOCS response stops leptin from reducing obesity. So weight goes up, which causes more inflammation. And the cycle starts all over again. Adiponectin is another key adipokine involved in weight control and inflammation.
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