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18 Nature. Interestingly, obese mice naturally produce nutritional copious resistin, says study coauthor Mitchell A. Lazar, a molecular endocrinologist at Pennsylvania. When given drugs that inhibit the effects of resistin, these overweight mice process glucose more efficiently, he says. The Pennsylvania researchers have identified the human nutritional gene that encodes resistin, but they haven't yet gauged the hormone's effects in people. Roughly four out of five nutritional people with type II diabetes are obese. The new findings "indicate that resistin may form at least part of the missing link between obesity and diabetes," says Jeffrey S. Flier of Beth Israel Deaconess Medical Center in Boston in the same issue of Nature. Lazar's team found resistin in mice while monitoring the effects of a diabetes medication in the family of drugs called TZDs, or thiazolidinediones. Earlier studies in rodents had shown that TZDs slow type II diabetes even though they spur the creation of fat cells, a seemingly contradictory action.
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