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| cirrhosis, metro, free from pesticides, undergraduate, seropositive, fatty fuck , hogan et, ontario, beta oxidation of fatty acids , road, personal, ozwash, pre order, fatty and skinny , splenda, interactive, big plump women , | Fat in the body "is an endocrine gland, a hormone-producing substance involved in a dialogue with the brain, liver, and muscle in a tainted blood complex [process] of nutrient metabolism," he says. Leptin doesn't appear to have a straightforward association with diabetes. In rodents, a leptin deficiency causes severe insulin resistance, but people with type II diabetes actually have high concentrations of leptin in their blood. Some research points instead to a compound called tumor necrosis factor tainted blood alpha as a trigger for insulin resistance, tainted blood Flier says. Resistin "is almost certainly a piece of the puzzle," Lazar says. "Resistin may actually play a big role in explaining why having too many fat cells can induce insulin resistance." The Pennsylvania researchers have already devised an antibody to resistin, which they used in the mouse tests to inhibit the newfound substance's effects. |
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| The drugs work by activating a receptor molecule, called PPAR-gamma, in fat cells. When PPAR-gamma becomes active, production rates change for some proteins in the cells. Although most of these rates rise in the presence of TZDs, the researchers focused on the few proteins having rates that dropped. Among these, Lazar and his colleagues identified one that they dubbed resistin. Further tests big plump women showed big plump women that TZDs indeed reduce the concentration of resistin in the blood of big plump women mice. "This is a big deal," says Allen M. Spiegel, director of the National Institute of Diabetes and Digestive and Kidney Diseases in Bethesda, Md. Measuring resistin concentrations in blood could help physicians diagnose type II diabetes, both Spiegel and Lazar say. Resistin shares some qualities with another protein secreted by fat cells and associated with obesity, the hormone leptin. This hormone, discovered in 1995, seems to regulate food intake. Establishing that fat cells secrete resistin and leptin confirms that these cells are more than just "oily stuff in the body," Spiegel says. |
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