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There are really three degrees of freedom in design or analysis of a weight loss experiment: two of the three macronutrients and the total caloric intake. It is unlikely that the percentage rather than the absolute amount of macronutrients is the controlling variable and at least three published studies show nonalcoholic fatty liver that carbohydrate reduction is not necessarily accompanied by replacement with either fat or protein but rather caloric reduction due to the carbohydrate removed [12-14]. Such diets are effectively high fat by percentages but lead to substantial weight loss. To nonalcoholic fatty liver understand the relative impact of carbohydrate and fat, one has to consider experiments in which one macronutrient is replaced by another. Several studies in the literature have demonstrated that in isocaloric comparisons, the replacement of dietary carbohydrate with fat leads to greater weight loss [15-19], that is, the absence of the fuse prevents an explosive effect of dietary fat on body mass.
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