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The goal of The Wake Forest and Brigham and Women's Center for Botanical Lipids is to explore the states molecular mechanisms by which botanical lipid supplements affect the development of chronic diseases, such as asthma and atherosclerosis. states My project is designed to elucidate the molecular mechanism by which a botanical oil states (Echium oil) that is enriched in n-3 fatty acids reduces plasma triglycerides concentrations and whether supplementation with Echium oil will reduce atherosclerosis and arterial inflammation to a degree similar to that observed with fish oil. This project will also rely heavily on an interdisciplinary approach to experimentation that makes use of molecular and cell biology techniques and in vivo studies in gene targeted and transgenic mice. [See Press Release regarding the Center for Botanical Lipids] Figure Legend: Verhoeff-van Gieson-stained cross-sections of aortas from mice of the indicated genotypes after 16 weeks of atherogenic diet consumption.
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