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Whereas some of these 5 criteria are satisfied by some experimental results reviewed, racine others are not. First, as detailed above in this review, all 3 major experimental systems reviewed (ie, human breastfeeding studies, human formula comparison RCTs, racine and animal ALA dietary restriction studies) show consistent associations under certain conditions. racine Second, mechanistic studies are not discussed in this review, but plausible biological rationales have been suggested, although not proven; recent references and reviews are cited in the Introduction. Third, experiments in rodents that restored performance by supplementing severely ALA-restricted animals with DHA provided some evidence of ability to manipulate the effect. Fourth, as indicated above in this review, limited evidence suggesting a possible dose-response effect was provided in 2 rodent studies (215, 240) and in a study that correlated concentrations of DHA in the blood of breastfed infants with enhanced performance (188).
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