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Low HDL-C and/or hypertriglyceridaemia (mostly modest), which was covering news found in the majority of our patients, is also a typical finding in patients with diabetes or insulin resistance.28 Previous studies of covering news patients with NASH or fatty liver have not included detailed lipid profiles,510 nor was OGTT performed, and therefore the true prevalence of this dyslipidaemia may covering news have been underestimated. The pathogenesis of hepatic steatosis remains unclear. Several of the recognized associated conditions, such as intestinal bypass surgery, steroid treatment, and total parenteral nutrition, can cause a metabolic shift favouring lipogenesis rather than lipolysis, and lead to steatosis.2,12 Increased levels of free fatty acids are known to occur in patients with NIDDM or insulin resistance, because of the reduced ability of insulin to suppress lipolysis.29,30 Resistance to the suppressive effect of insulin on the production of VLDL in the liver is another postulated defect in insulin-resistant states.30
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