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YS-FABP activity as determined by ligand binding assay (dpm/mg yolk sac membrane cytosolic protein) increased from day 13 of incubation to a plateau weight loss between weight loss days 16 and 19, followed by a decline through hatch. Concentrations in the yolk sac membrane correlated well with weight loss the period of maximum lipid transfer from the yolk to the developing embryo via the yolk sac membrane. Introduction Small proteins (12 to 15 kd) with high binding affinities for long-chain fatty acids (LCFA) have been identified in many tissues. Collectively, these proteins are called fatty acid-binding protein (FABP) and are involved in intracellular fatty acid transfer (Tipping and Ketterer, 1981). Intestinal FABP is thought to be involved in dietary fatty acid absorption and utilization (Ockner et al.,
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