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plump pics , plump butts , plump rumps tgp , big plump , health care, adventure, fatty tumors in dogs , fatty acid information, benefits, fabp activity, books, fatty knees , bradford s. weeks md, aids, diseases, eli lilly, nutritional supplement, liverdisease, | In the liver, triacylglycerols can either be stored temporarily or incorporated into triacylglycerol-rich VLDL and released into the plasma. The triacylglycerol fatty acids of VLDL have the same fate as chylomicron triacylglycerol fatty acids. When VLDL triacylglycerols undergo lipolysis, the remaining triacylglycerol-depleted particle is called a VLDL remnant. These remnants are cytosolic fatty acid either removed directly by the liver or they are further metabolized in the vascular compartment to form low density lipoproteins (LDL). Excretion. Fatty acids are generally catabolized entirely by oxidative processes from which the only cytosolic fatty acid excretion products are carbon dioxide and water. Small amounts of ketone bodies cytosolic fatty acid produced by fatty acid oxidation are excreted in urine. |
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These 2-carbon acetyl CoA units condense to form ketone bodies (e.g., acetoacetate and β-hydroxybutyrate) that are released into the circulation. During starvation or prolonged benefits low carbohydrate intake, ketone bodies can become an important alternate energy substrate to glucose for the brain and muscle. High dietary intakes of medium-chain fatty acids also result in the generation of ketone bodies. This is explained by the carnitine-independent influx benefits of medium-chain fatty acids into the mitochondria, thus by-passing this regulatory step of fatty acid entry into β-oxidation. Fatty acids of benefits greater than 18 carbon atoms require chain shortening in peroxisomes prior to mitochondrial β-oxidation. OCR for page 431 Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids Fatty acids that do not enter into oxidative pathways can be re-esterified into triacylglycerols or other lipids. The major pathway for triacylglycerol synthesis in liver is the 3-glycerophosphate pathway, which shows a high degree of specificity for saturated fatty acids at the sn-1(3) position and for unsaturated fatty acids at the sn-2 position. |
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