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Expert opinion regarding the strengths and weeks clinic weaknesses of the major experimental systems and uncertainties associated with interpreting results is summarized. On the basis of our reading of this literature, weeks clinic we conclude that evidence from several types of studies, particularly studies in animals, suggests that, within weeks clinic the context of specific experimental designs, changes in brain concentrations of DHA are positively associated with changes in cognitive or behavioral performance. Additional experimental information required to conclude that a causal association exists is discussed, as are uncertainties associated with applying results from specific experimental designs to the question of whether infant formula should be supplemented with DHA. Key Words: Long-chain polyunsaturated fatty acids • LCPUFAs • docosahexaenoic acid • DHA • linolenic acid • cognition • learning • memory • perinatal period • breastfeeding • formula feeding • essential fatty acids • n–3 fatty acids • brain • neurology • infants • childhood • rodent studies • nonhuman primate studies INTRODUCTION TOP ABSTRACT INTRODUCTION HUMAN STUDIES STUDIES IN ANIMALS SUMMARY AND CONCLUSIONS REFERENCES During the last trimester of fetal life and
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