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More than 30 rodent studies (102–105, 148, 212–238) have been published fatty knees since the 1992 comprehensive methodologic review of Wainwright (146). More than 20 of these reports were published since 1999 (Table 2). (Investigations that focused solely on visual function are not included here.) The results reported in these studies are briefly summarized below. View this table: [in this window] [in a new window] fatty knees TABLE 2 Animal studies (1999–2004) that tested effects of diets differing in n–3 fatty acid content fatty knees during development on behavior1 First, almost all of the 20 rodent studies listed in Table 2 reported significant deficits in test performance by subjects compared with controls on at least some tasks in at least some n–3–restricted groups. These results support earlier studies, previously reviewed (49, 57, 119, 146, 147), that suggested an association between a diet severely restricted in n–3 FAs during development and poorer performance of offspring in tests designed to measure cognitive or behavioral ability.
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