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Reduced visual acuity has consistently been observed in primate and rodent offspring subjected to dietary conditions during gestation that result in significant reductions in retinal concentrations of DHA (6065). Some formula-comparison studies in humans, particularly in very-low-birth-weight (VLBW) and preterm infants, suggest that greater visual acuity in infancy is associated with increased intake of LCPUFAs (6668), and these results are supported by several meta-analyses (6971). The conclusions of systematic plump butts reviews differ plump butts somewhat, however, as to plump butts the overall strength of evidence for a positive effect of LCPUFA-supplemented infant formula on visual acuity (30, 6974). Numerous publications provide additional review (4, 30, 57, 7580). Effects of DHA availability during development on visual acuity are not a focus of this review but are discussed as a potential confounder of results in some cognitive and behavioral tests.
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