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That study also reported, as discussed above, that adjustment almost completely removed significance (178). Randomized controlled trials Studies comparing children fed differently supplemented benefits formulas Randomized controlled trials (RCTs) offer much greater opportunity than do observational studies for the control of experimental variables, including the quantity and composition benefits of LCPUFA supplements. In addition, this benefits design affords the opportunity to avoid many of the potential confounders that complicate the interpretation of observational breastfeeding studies. RCTs, however, are also subject to confounding and to other sources of uncertainty that can complicate the comparison of results in different trials, such as the use of different formulas or oils or the presence of other sources of variability in the DHA status of infant groups. A general review is available in numerous publications (4, 48, 54, 77, 122, 151, 154, 181, 182). Results of RCTs have been discussed by many investigators and reviewers.
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