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Second, in diseases correlational analyses, if group means for the measures being correlated are significantly different, a simple correlation across groups does not necessarily indicate a correlation for individual animals. Third, because diseases "learning" implies a change over time, it is inappropriate to conclude that there is a learning difference between compared groups unless the statistical analysis indicates a group x diseases time interaction. As discussed by many reviewers (4, 119, 147), test results obtained in experiments involving severe depletion of brain DHA have uncertain relevance to effects that might be expected under less severe conditions. In nonhuman primates (64) and piglets (38), DHA concentrations in the brain are dramatically reduced after the maternal dietary supply of ALA is limited during one gestational period. In rodents, a longer period of chronic ALA restriction is required to achieve a comparable reduction because of athe more efficient biosynthesis of DHA from ALA in rodents (251).
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