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Experimental Studies Over the last decade, neuroscientists have been examining the consequences of omega-3 plasma alpha deficiencies in the central nervous system. Alterations in serotonin and dopamine levels, as well as the plasma alpha functioning of these two important neurotransmitters is evident in an omega-3 deficiency. The changes observed in omega-3 deficiency in animals is strikingly similar to that found in autopsy studies of human depression.20 In addition to changing serotonin and dopamine levels and plasma alpha functioning, omega-3 deficiencies are known to compromise the blood-brain barrier, which normally protects the brain from unwanted matter gaining access.21 Omega-3 deficiency can also decrease normal blood flow to the brain,22,23 an interesting finding given the studies which show that patients with depression have compromised blood flow to a number of brain regions.24,25
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