5.25 g/d) and found developmental expression diet

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5.25 g/d) and found no increase in fecal fat excretion (5) (23) . In this study, subjects ate an average of 132 g of fat and took 4.5 g of chitosan daily. Based on the package claims (10.8 mL of diet fat bound per gram active ingredient), we would expect 44 g of dietary fat to be bound (10.8 mL x 0.90 g/mL x 4.5 g chitosan) and excreted in the diet feces. Only 1.1 g of extra fat was actually diet excreted in the feces. Thus, the calculated in vivo binding capacity per gram of chitosan amounts to 0.25 g of fat per gram of chitosan. To achieve a 50% reduction in fat digestibility in these subjects at this rate of binding, 264 g of this product, or 587 capsules per day, would theoretically be needed. In those studies where an increase of fecal fat was observed in rodents consuming massive quantities of chitosan, there was also an increase of fat as percent of fecal mass (19) (21) .
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