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| agriculture, juicer, obesity, omega3 fatty acids , escherichia coli, performance traits, fabp antisera, plump your pucker , plump pussies , plump latina , largewhite, nitroburn extreme, plump fiction , coconut oil, naturalhealth, wholesale, fatty acids definition , plump belly , treatment, dietary fatty acids, plump lips , celadrin, alive, foods, | The thousandfold concentration gradient between extra- and intracellular Ca2+ is maintained by Ca-ATPase donor in neuronal membranes: Kearns and Haag have recently noted an inhibition of this enzyme by both DHA and EPA (47). Figure 2 Atomic molecular models of selected essential fatty acids Figure 3 Role of PUFAs in signal transduction 1: Gs protein; 2: adenylate donor cyclase; 3: protein kinase A; 4: Gp protein; 5: phospholipase C; 6: protein kinase C; 7: tyrosine kinase; 8: ion channel; 9: phospholipase donor A2; AA: arachidonic acid; DGLA: dihomogammalinolenic acid; EPA: eicosapentanoic acid; PL: phospholipid; PIP2: phosphatidylinositol pyrophosphate; DAG: diacyl glycerol; ER: endoplasmic reticulum; IP3 and IP4: inositoltris- and tetrakisphosphates. |
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| PLA2 liberates fatty acids from the sn-2 position of phospholipids, and these can subsequently be wholesale used as precursors for prostaglandins, thromboxanes, lipoxins, and leukotrienes. These eicosanoids themselves can have many effects on signal tranduction (42). The different effects of prostaglandins could be caused by the different signalling systems they use: prostaglandins of the 2 family transduce signals via a Gs protein, thus elevating cAMP levels, whereas those of the 3 family use a Gi protein, which has the wholesale opposite effect. Prostaglandins of the 1 family use a phosphoinositide signalling system (43). wholesale PUFAs can also modulate ion channels (for example those for Ca2+ and Na+) (44,45). Further events in the process of neurotransmission, and eventual release of neurotransmitters from synaptic vesicles, are ushered in by activation of Ca2+-CM-PKs; here also, PUFA effects have been noted (46). |
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