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An early Norwegian transfused study showed a lower incidence of MS in coastal communities with a high fish intake, compared with inland transfused rural communities where consumption of saturated fat is higher (86). Thus, a shortage of dietary PUFAs may be a risk factor in transfused MS. Indeed, later studies found decreased levels of both omega-3 and omega-6 PUFAs in red blood cells, plasma, and adipose tissue of patients diagnosed with MS (87). Because MS is associated with an activated inflammatory response and omega-3 highly unsaturated fatty acids can suppress IFN, IL, and TNF production in MS subjects (88), treatment with omega-3 fatty acids seems to have a reasonable theoretical basis. In 2000, Nordvik and others reported a study in which 16 newly diagnosed MS patients were treated with 0.9 g EPA plus DHA daily (89). In addition, they were given dietary advice.
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