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The 1996 report of Adams and coworkers supported this hypothesis (72). These researchers showed a significant positive correlation in 20 subjects between depression fatty acid manufacturers severity (measured according to the Hamilton Depression Rating Scale as well as a linear scale that omits anxiety) and the ratio fatty acid manufacturers of AA (omega-6) to EPA (omega-3) in erythrocyte phospholipids. In a similar vein, Edwards and others reported a significant depletion of omega-3 PUFAs in the red blood cell membranes of 10 subjects with a fatty acid manufacturers diagnosis of a major depressive episode according to DSM-IV criteria, compared with matched normal control subjects (73). This study rated participants according to the Beck Depression Inventory and controlled fully for possible confounders such as diet, smoking, and stress. Maes and colleagues have since also reported trials with similar results (74,75).
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